Groups


Within the CHAIN Network, areas of focus are organized around “working groups” comprised of, and led by, members of the Network. Each working group aims to address questions important to a particular area of research believed to be critical for reducing childhood mortality.

Social & Behavioral Science

Team Leaders: Dr. Sassy Molyneux
Acute illness and undernutrition in children usually occur against a background of social and economic disadvantage. It is conceivable that no amount of nutritional or anti-infective interventions will be effective in preventing longer te...

Nutrition & Metabolism

Team Leaders: Dr. Robert Bandsma ‘Undernutrition’ encompasses a range of macro- and micronutrient deficiencies that usually co-exist. For children with acute illness, metabolic disturbances affect nutrient metabolism, energy product...

Causes of Death

Team Leaders: Dr. Wieger Voskuijl
The causes of death among malnourished children are hard to elucidate and not well understood. The gold standard in establishing cause of death is to conduct post mortem studies but these are limited by social and cultural barriers. This ...

Respiratory Disease and Tuberculosis

Team Leaders: Dr. Chisti Jobayer
Many clinicians suspect that undiagnosed tuberculosis (TB) may be responsible for many cases of acute illness and malnutrition. However, TB is notoriously difficult to diagnose in children. A significant proportion of inpatient and post-d...

Immunity & Invasive Infection

Team Leaders: Professor Jay Berkley
Children with malnutrition are at increased risk of life-threatening infection, even after therapeutic feeding. However, the nature of immunological dysfunction is unclear and only a small proportion of children with a sepsis-like clinica...

Enteric function and infection

Team Leader: Dr. Donna Denno
The enteric system is critical for the maintenance of normal immune function, and nutrient absorption. Alterations in the biology of the gut caused by pathogens or medical intervention may be associated with poor recovery from acute illne...

Undernutrition in Infancy

Team Leader: Dr. Martha Mwangome Malnourished infants experience very high mortality and incidence of severe infections such as pneumonia and diarrhoea. However, nutritional rehabilitation guidelines for infants under 6 months are curren...

Acute Care and Monitoring

Team Leader: Dr. Judd L. Walson
Children with malnutrition and an acute illness often die unexpectedly, usually with a rapid deterioration preceded by few warning signs. Unlike well-nourished children, mortality often occurs late in the hospitalization period or after d...

Neuro-cognitive development

Team Leader: Dr Ezekiel Mupere
Malnutrition can impair the neurocognitive development of a child which can lead to extended disabilities and impact their survival. In low resource settings, little is known about the prevalence of neurodevelopmental disability and its i...